Laboratory of Lorraine S. Symington, Ph.D
Professor of Microbiology & Immunology

Selected Publications


Ho, C.K., Mazon, G., Lam, A.F. and Symington, L.S. (2010) Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. Molecular Cell 40: 988-1000.


Marrero, V.A. and Symington, L.S. (2010) Extensive DNA end processing by Exo1 and Sgs1 inhibits break-induced replication. PLoS Genetics 6: e1001007.


Mimitou, E.P. and Symington, L.S. (2010) Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO Journal 29: 3358-3369.


Smith, C.E., Lam, A.F. and Symington, L.S. (2009) Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase δ complex. Mol. Cell. Biol. 29: 1432-1441.


Ho, C.K., Lam, A.F. and Symington, L.S. (2009) Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome. PloS ONE 4: e6993.


Fung, C.W., Mozlin, A.M. and Symington, L.S. (2009) Suppression of the double-strand break repair defect of the Saccharomyces cerevisiae rad57 mutant. Genetics 181: 1195-1206.


Mimitou, E.P. and Symington, L.S. (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.


Malik, P.S. and Symington, L.S. (2008) Rad51 gain-of-function mutants that exhibit high affinity DNA binding casue DNA damage sensitivity in the absence of Srs2. Nucleic Acids Res. 36: 6504-6510.


Mozlin, A.M., Fung, C.W. and Symington, L.S. (2008) Role of the Saccharomyces cerevisiae Rad51 paralogs in sister-chromatid recombination. Genetics 178: 113-126.


Smith, C.E., Llorente, B and Symington, L.S. (2007) Template switching during break-induced replication. Nature 447: 102-105.


Krogh, B.S., Llorente, B., Lam, A. and Symington, L.S. (2005) Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics 117: 1561-70.


Langston, L.D. and Symington, L.S. (2004) Gene targeting in yeast is initiated by two independent strand invasions. Proc. Natl. Acad. Sci. USA 101: 15392-15397.