Laboratory of Stephen P. Goff, Ph.D
Professor of Biochemistry & Molecular Biophysics and Microbiology & Immunology

Selected Publications

Kao, T.-H., Liao, H.-F., Wolf, D., Tai, K.-Y., Chuang, C.-Y., Lee, H.-S., Kuo, H.-C., Hata, K., Zhang, X., Cheng, X., Goff, S.P., Ooi, S.K., Bestor, T.H. and Lin, S.-P. (2014) Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells. J. Virol., in press.

Arriagada, G., Metzger, M.J., Muttray, A., Sherry, J., Reinisch, C., Street, C., Lipkin, W.I. and Goff, S.P. (2014) Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria. Proc. Natl. Acad. Sci. USA, in press.

Schlesinger, S., Meshorer, E. and Goff, S.P. (2014) Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells. Retrovirology 11: e31.

Wang, G.Z., Wolf, D. and Goff, S.P. (2013) EBP1, a novel host factor involved in Primer Binding Site (PBS)-dependent restriction of Moloney murine leukemia virus in embryonic cells. J. Virol. 88: 1825-1829.

Goff, S.P. (2013) HIV: Slipping under the radar. Nature News and Views 503: 352-353.

Sabo, Y., Walsh, D., Barry, D.S., Tinaztepe, S., de los Santos, K., Goff, S.P., Gundersen, G.G. and Naghavi, M.H. (2013) HIV-1 induces the formation of stable microtubules to enhance early infection. Cell Host Microbe 14: 535-546.

Schlesinger, S., Lee, A., Wang, G.Z., Green, L. and Goff, S.P. (2013) Proviral silencing in embryonic cells is regulated by Yin Yang 1. Cell Rep. 4: 1-9.

Lukic, Z., Goff, S.P., Campbell, E.M. and Arriagada, G. (2013) Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5a-mediated restriction. Retrovirology 10: e10.

Beyer, A.R., Bann, D.V., Rice, B., Pultz, I.S., Kane, M., Goff, S.P., Golovkina, T.V. and Parent, L.J. (2013) Nucleolar trafficking of the mouse mammary tumor virus Gag protein induced by interaction with ribosomal protein L9. J. Virol. 87: 1069-1082.

Schlesinger, S. and Goff, S.P. (2013) Silencing of proviruses in embryonic cells: Efficiency, stability, and chromatin modifications. EMBO Rep. 14: 73-79.

Green, L., Houck-Loomis, B., Yueh, A. and Goff, S.P. (2012) Large ribosomal protein 4 increases efficiency of viral recoding sequences. J Virol. 86: 8949-8958.

Goff, S.P. (2012) Retroviridae: The Retroviruses and their Replication. In Fields Virology, sixth edition (Knipe, D. and Howley, P., eds.), Lippincott Williams & Wilkins, Philadelphia PA, Chapter 47, 1424-1473.

Arriagada, G., Muntean, L.N. and Goff, S.P. (2011) SUMO-interacting motifs of human TRIM5alpha are important for antiviral activity. PLoS Pathog. 7: e1002019.

Hogg, J.R. and Goff, S.P. (2010) Upf1 senses 3' UTR length to potentiate mRNA decay. Cell 143: 379-389.

Qiu, Z.Z., Cang, Y. and Goff S.P. (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc. Natl. Acad. Sci. U.S.A. 107: 1136-1141.

Valente, S.T., Gilmartin, G.M., Venkataraman, K. and Goff, S.P. (2009) HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Mol. Cell 36: 279-289.

Wolf, D. and Goff, S.P. Embryonic stem cells use ZFP809 to silence retroviral DNAs. (2009) Nature 458: 1201-1204.

Valente, S.T., Gilmartin, G.M., Mott, C., Falkard, B. and Goff S.P. (2009) Inhibition of HIV-1 replication by eIF3f. Proc. Natl. Acad. Sci. U.S.A. 106: 4071-4078.

Wolf, D., Hug, K. and Goff S.P. (2008) TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells. Proc. Natl. Acad. Sci. USA 105, 12521-12526.

Wolf, D. and Goff, S.P. (2007) TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131: 46-57.

Cang, Y., Zhang, J., Nicholas, S.A., Kim, A.L., Zhou, P. and Goff, S.P. (2007) DDB1 is essential for genomic stability in developing epidermis. Proc. Natl. Acad. Sci. USA 104: 2733-2737.

Cang, Y., Zhang, J., Nicholas, S.A., Bastien, J., Li, B., Zhou, P. and Goff, S.P. (2006) Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127: 929-940.

Naghavi, M.H., Hatziioannou, T., Gao, G. and Goff S.P. (2005) Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. Genes Dev. 19: 1105-1115.

Evans, M.J., Rice, C.M. and Goff, S.P. (2004) Phosphorylation of Hepatitis C virus NS5A modulates its protein interactions and viral RNA replication. Proc. Natl. Acad. Sci. U.S.A. 101: 13038-13043.

Orlova, M., Yueh, A., Leung, J. and Goff, S.P. (2003) Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Cell 115: 319-331.

Gao, G., Guo, X. and Goff, S.P. (2002) Inhibition of retroviral RNA production by ZAP, a novel CCCH-type zinc finger protein. Science 297: 1703-1706.

Tachedjian, G., Orlova, M., Sarafianos, S., Arnold, E. and Goff, S.P. (2001) Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type1 reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 98: 7188-7193.

Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S.L., Tondravi, M.M. and Goff, S.P. (2000) Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat. Genet. 24: 304-308.

Yuan, B., Li, X. and Goff, S.P. (1999) Mutations altering the Moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle. EMBO J. 18: 4700-4710.