Department of Microbiology & Immunology

Columbia University in the City of New York
Stephen Emerson, M.D., Ph.D.
Clyde and Helen Wu Professor of Immunology (in Medicine), Professor of Microbiology & Immunology and Director of the Herbert Irving Comprehensive Cancer Center
M.D., Ph.D., Yale University

Regulation of hematopoietic stem cell proliferation and transplantation immunology

Research
Our laboratory studies the transcriptional regulation of hematopoietic stem cell (HSC) proliferation, self-renewal and differentiation. In particular we focus on NF-Y, the inducible transcriptional regulator of Hox-X4 genes, Bmi-1, the polycomb complex protein, and telomerase. We also study the orphan nuclear hormone receptor Nur77 with the laboratory of Jennifer Punt. Within the context of HSC engraftment, we are interested in immune inputs into HSC proliferation, including the effects of interferons and other products of activated T lymphocytes in the context of graft-versus-host disease.

Selected Publications

  1. Bungartz, B., Land H. and Emerson, S.G. (2012) NF-Y is a key regulator of hematopoietic stem cell (HSC) regulatory genes and is essential for cycling but not quiescent HSCs. Blood 119: 1380-1389.
  2. Reshef, R., Luger, S.M., Hexner, E.O., Loren, A.W., Frey, N.V., Nasta, S.D., Goldstein, S.C. Stadtmauer, E.A. Smith, J., Bailey, S., Mick, R., Heitjan, D.F., Emerson, S.G., Hoxie, J.A., Vonderheide, R.H. and Porter, D.L. (2012) Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. New England Journal of Medicine 367: 135-145.
  3. Zhang, Y. Sandy, A.R, Wang, J., Kato, K., He, S., Tran, I., Shan, G.T., Friedman, A., Hexner, E., Emerson, S.G., Pear, W.S. and Maillard, I. (2011) Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease. Blood 177: 299-308.
  4. Kato, K., Cui, S., Kuick, R., Mineishi, S., Hexner, E., Ferrara, J.L.M., Marquez, V.E., Emerson, S.G. and Zhang, Y. (2010) CD8+ effector T cells proliferate and persist upon chronic exposure to alloantigens through reactivation of stem cell transcriptional programs. Biol. Blood Marr. Transpl. 16: 755-771.
  5. Domashenko, A.D., Danet-Desnoyers, G., Aron, A., Carroll, M.P. and Emerson, S.G. (2010) TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells. Blood 116: 2676-2683.

Professor Stephen Emerson
Director, Herbert Irving Comprehensive Cancer Center
Phone: 212-851-4764
Fax: 212-851-4660
Email:  semerson@columbia.edu


Department of Microbiology & Immunology, Columbia University + 701 W. 168 St., HHSC 1208 New York, NY 10032 Tel. 212-305-3647