Laboratory of Lei Ding, Ph.D
Assistant Professor of Rehabilitation & Regenerative Medicine
and Microbiology & Immunology

Selected Publications

Decker, M., Leslie, J., Liu, Q. and Ding, L. (2018) Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance. Science 360: 106-110.

Jeong, M., Park, H.J., Celik, H., Ostrander, E.L., Reyes, J.M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., Guryanova, O.A., Li, W., Goodell, M.A., Challen, G.A. (2018) Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo. Cell Reports 23: 1-10.

Sarkaria, S.M., Decker, M. and Ding, L. (2018) Bone marrow micro-environment in normal and deranged hematopoiesis: Opportunities for regenerative medicine and therapies. BioEssays 40 doi: 10.1002/bies.201700190. Epub 2018 Jan 31.

Hirata, Y., Furuhashi, K., Ishii, H., Li, H.W., Pinho, S., Ding, L., Robson, S.C., Frenette, P.S. and Fujisaki, J. (2018) CD150high bone marrow Tregs maintain hematopoietic stem cell quiescence and immune privilege via adenosine. Cell Stem Cell 22: 445-453.

Lee, Y., Decker, M., Lee, H. and Ding L. (2017) Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases. Wiley Interdiscip. Rev. Dev. Biol. doi: 10.1002/wdev.279.

Park, D.Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H.G., Ding, L., Kim, J.W., Kim, H., He, Y., Adams, R.H. and Koh, G.Y. (2017) Plastic roles of pericytes in the blood-retinal barrier. Nature Communications 8: 15296.

Decker, M., Martinez-Morentin, L., Wang, G., Lee, Y., Liu, Q., Leslie, J. and Ding, L. (2017) Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis. Nature Cell Biology 19: 677-688.

Ding, L. (2017) HSC niche: ample room for every guest stem cell. Blood 129: 2042-2043.

Jiang, N., Chen, M., Yang, G., Xiang, L., He, L., Hei, T.K., Chotkowski, G., Tarnow, D.P., Finkel, M., Ding, L., Zhou, Y. and Mao, J.J. (2016) Hematopoietic stem cell in neural-crest derived bone marrow. Scientific Reports 6: 36411.

Sawai CM, Babovic S, Upadhaya S, Knapp DJ, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B. (2016) Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals. Immunity doi 10.1016/j.immuni.2016.08.007

Zhou, B., Ding, L. and Morrison, S.J. (2015) Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1. Elife 4: e05521.

Hayakawa, Y., Ariyama, H., Stancikova, J., Sakitani, K., Asfaha, S., Renz, B.W., Dubeykovskaya, Z.A., Shibata, W., Wang, H., Westphalen, C.B., Chen, X., Takemoto, Y., Kim, W., Khurana, S.S., Tailor, Y., Nagar, K., Tomita, H., Hara, A., Sepulveda, A.R., Setlik, W., Gershon, M.D., Saha, S., Ding, L., Shen, Z., Fox, J.G., Friedman, R.A., Konieczny, S.F., Worthley, D.L., Korinek, V. and Wang, T.C. (2015) Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche. Cancer Cell 28: 800-814.

Burberry, A., Zeng, M.Y., Ding, L., Wicks, I., Inohara, N., Morrison, S.J. and Nunez, G. (2014) Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. Cell Host Microbe 15: 779-791.

Chaix, J., Nish, S.A., Lin, W.H., Rothman, N.J., Ding, L., Wherry, E.J. and Reiner, S.L. (2014) Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. J. Immunol. 193: 1013-1016.

Oguro, H., Ding, L. and Morrison, S.J. (2013) SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell 13:102-116.

Ding, L. and Morrison, S. (2013) Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature dpi:10.1038. Published online Feb 24, 2013.

Ding, L., Saunders, T., Enikolopov, G. and Morrison, S. (2012) Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481: 457-462.

Ding, L. and Han, M. (2007) GW182 family proteins are critical for miRNA-mediated gene silencing. Trends in Cell Biology 17: 411-416.

Zhang, L.*, Ding, L.*, Cheung, T., Dong, M., Chen, J., Sewell, A., Liu, X., Yates, J. and Han, M. (2007) Systematic identification of miRISC proteins, miRNAs, and their mRNA targets in C. elegans by their interactions with GW182 family proteins AIN-1 and AIN-2. Molecular Cell 28:598-613 (*equal contribution)

Ding, L., Spencer, A., Morita, K. and Han, M. (2005). The developmental timing regulator AIN-1 interacts with argonaute protein ALG-1, miRISCs and may target ALG-1 to cytoplasmic P bodies in C. elegans. Molecular Cell 19: 437-447.